For more than 40 years, TISSEEL fibrin sealant has been trusted worldwide for proven hemostasis and sealing*. TISSEEL is the only fibrin sealant indicated for both hemostasis and sealing, adjunctive hemostasis in pediatric patients, and use in heparinized patients1, TISSEEL is also effective in patients medicated with antiplatelet drugs¹. *to prevent leakage from colonic anastomoses following the reversal of temporary colostomy  
See Indications
Tisseel Syringe


Ready when you are, the new applicator technology

  • Saves Time- Eliminates the need for external gas sources, saving valuable OR setup time2
  • Dual functionality- Gasless Spray Tip delivers your choice of broad spray or precise drip2
  • Open or Laparoscopic- Your choice of Open, 25 cm MIS and 40 cm MIS spray applicators
  • Quick Connect- Secure Snap Lock attachment to PRIMA syringe2
Two black and white images of clots - a physiological clot and a TISSEEL clot

Mimics Physiological Clot

TISSEEL contains a unique formulation of fibrinogen and thrombin which, upon mixing, mimics a physiological clot. The aprotinin in TISSEEL increases resistance of the fibrin sealant clot to degradation in a fibrinolytic environment1.

Selected Risk Information: Do not use TISSEEL in individuals with a known hypersensitivity for aprotinin. Please see important risk information for additional details.

Mechanism of Action

Upon mixing, human sealer protein and human thrombin combine into fibrin that adheres to the wound surface and achieves hemostasis and sealing. TISSEEL mimics the final coagulation cascade step by forming a clot. Learn more about how TISSEEL works.

Additional Product Benefits

Wide Range of Applicators

TISSEEL is the only fibrin sealant to offer a complete portfolio of drip and spray applicators, allowing surgeons to select the right tools to address individual patient needs.

Precise Placement

The DUPLOSPRAY System allows for bleeding to be targeted laparoscopically by getting as close as 2-5 cm to the tissue¹.


Do not spray TISSEEL where the recommended minimum distance from the applicator tip to the target site cannot be assured. Please see full Prescribing Information for recommended distances and pressure.

Indications and Important Risk Information

TISSEEL [Fibrin Sealant] Indications

Hemostasis: TISSEEL is a fibrin sealant indicated for use as an adjunct to hemostasis in adult and pediatric patients (> 1 month of age) undergoing surgery when control of bleeding by conventional surgical techniques (such as suture, ligature, and cautery) is ineffective or impractical. TISSEEL is effective in heparinized patients.

Sealing: TISSEEL is a fibrin sealant indicated as an adjunct to standard surgical techniques (such as suture and ligature) to prevent leakage from colonic anastomoses following the reversal of temporary colostomies.


Important Risk Information for TISSEEL [Fibrin Sealant]

For Topical Use Only. Do not inject TISSEEL directly into the circulatory system or into highly vascularized tissue. Intravascular application of TISSEEL can lead to intravascular coagulation, can result in life- threatening thromboembolic events, and can increase the likelihood and severity of acute hypersensitivity reactions in susceptible patients. To minimize the risk of intravascular application, exercise caution when using TISSEEL in surgery.

Do not use TISSEEL in individuals with a known hypersensitivity to aprotinin.

Do not use TISSEEL for treatment of severe or brisk arterial or venous bleeding. In these situations, TISSEEL will be washed away in the flow of blood before hemostasis can be attained.

Do not spray TISSEEL where the minimum recommended distance from the applicator tip to the target site cannot be assured.

Hypersensitivity or allergic/anaphylactoid reactions can occur with the use of TISSEEL. Such reactions may especially be seen if TISSEEL is applied repeatedly over time or in the same setting, or if systemic aprotinin has been administered previously.

Aprotinin is known to be associated with anaphylactic reactions. Even in the case of strict local application of aprotinin, there is a risk of anaphylactic reactions to aprotinin, particularly in the case of previous exposure.

Discontinue administration of TISSEEL in the event of hypersensitivity reactions. Remove remaining product from the application site.

Air or gas embolism has occurred when fibrin sealant was administered using pressurized gas. This can occur if a spray device is used at higher than recommended pressures and in closer than recommended proximity to the tissue surface.

When using the EASYSPRAY device, or an equivalent spray device for open surgical procedures cleared by FDA, TISSEEL must not be sprayed in enclosed body areas and must be sprayed onto only visible application sites.

TISSEEL is denatured when exposing to solutions containing alcohol, iodine or heavy metals. If any of these substances have been used to clean the wound area, the area must be thoroughly rinsed before the application of TISSEEL.

Apply TISSEEL as a thin layer by dripping or spraying using cannula or spray set. Excess clot thickness can negatively interfere with wound healing.

The safety and effectiveness of TISSEEL used alone or in combination with biocompatible carriers in neurosurgical procedures or other surgeries involving confined spaces have not been evaluated; its use in this setting is not FDA approved.

TISSEEL is made from human plasma. It may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

Please see accompanying full Prescribing Information

Gasless Tip Applicator Instructions for Use